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HRT in perimenopause
Empowered Perimenopause With Francesca Liparoti
Episode 99: HRT in Perimenopause: What I Wish Every Woman Knew Before Starting HRT
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For many women, HRT feels like one of the biggest decisions they’ll make during perimenopause.

Should I start it?

Am I too young?

Am I too old?

Is it safe?

Will it help me?

What if I don’t want to take it?

It’s no wonder so many women feel confused.

For years we’ve been surrounded by conflicting headlines, changing guidance and very different personal experiences. One friend describes HRT as life-changing, while another says it wasn’t right for her. Some healthcare professionals actively recommend it, while others remain more cautious.

So where does that leave you?

In this week’s episode of Empowered Perimenopause, I wanted to step away from the noise and offer something different.

Not another debate about whether HRT is “good” or “bad.”

Instead, a calm, balanced conversation about what I genuinely wish every woman understood before making her own decision.

Because HRT isn’t about following what everyone else is doing.

It’s about understanding your own body and making an informed choice that’s right for you.

HRT Is One Tool, Not the Whole Toolbox

One of the biggest messages I hope women take away from this episode is that HRT doesn’t have to be viewed as an “all or nothing” decision.

If you’ve been following my recent Whole-Body Shift podcast series, you’ll know that we’ve explored how every system in the body is connected.

Our hormones influence our nervous system.

Our sleep affects our blood sugar.

Our muscles influence our metabolism.

Our gut supports hormone metabolism.

Everything works together.

HRT fits into that picture.

It doesn’t replace it.

For some women, HRT can be incredibly supportive, helping to reduce symptoms such as hot flushes, night sweats, poor sleep, anxiety, low mood and vaginal dryness. It may also offer longer-term benefits for bone health and, for some women, cardiovascular and brain health.

But even when HRT is the right choice, it doesn’t replace the importance of nourishing your body well, building strength, managing stress or prioritising sleep.

Those foundations still matter.

In fact, they often work even better alongside one another.

Why Every Woman’s Experience Is Different

One of the questions I hear most often is:

“Why did HRT completely transform my friend’s life when another friend stopped taking it because she felt worse?”

The answer is actually quite simple.

No two women arrive at perimenopause in exactly the same place.

We all have different genetics.

Different lifestyles.

Different medical histories.

Different hormone fluctuations.

Different symptoms.

One woman may already have significantly declining hormone levels and experience remarkable improvements with HRT.

Another woman of exactly the same age may still be producing plenty of oestrogen but experiencing dramatic fluctuations. In those circumstances, introducing additional hormones may feel very different.

This is one of the reasons I encourage women not to compare their own journey with somebody else’s.

Your friend’s experience isn’t a prediction of yours.

It’s simply her story.

Your body deserves an individual approach.

The Conversation Around HRT Has Changed

Many women are understandably confused because the advice around HRT seems very different today than it did twenty years ago.

The truth is that our understanding has evolved.

Much of the concern surrounding HRT came from the Women’s Health Initiative study published in the early 2000s. Those findings created widespread concern about breast cancer and heart disease, leading many women to stop HRT and many doctors to prescribe it much more cautiously.

As researchers continued analysing the evidence, however, a more detailed picture emerged.

The women involved in that study were generally older than women who begin HRT today.

Many started treatment long after menopause.

The types of hormones used also differed from the body-identical hormones commonly prescribed today.

What we now understand is that timing matters.

The type of hormone matters.

The dose matters.

The route of delivery matters.

Most importantly…

The individual woman matters.

Rather than asking whether HRT is “safe” in general, today’s conversations are increasingly focused on whether it’s appropriate for a particular woman based on her symptoms, health history and individual circumstances.

Body-Identical Hormones Explained

Another area that often causes confusion is the difference between body-identical hormones and synthetic hormones.

Body-identical oestrogen and progesterone have the same molecular structure as the hormones naturally produced by the body.

Oestrogen is commonly prescribed as a gel, patch or spray, while women who still have a womb are usually prescribed micronised progesterone alongside it to protect the lining of the womb.

These are very different from the synthetic hormones used in most contraceptive pills.

Although some women assume they’ll react to HRT in the same way they reacted to the pill, that’s often not the case because the hormones themselves are different and they’re being used for a different purpose.

What Happens After Oestrogen Has Done Its Job?

One aspect of HRT that isn’t discussed nearly enough is what happens after the hormones have done their job.

Oestrogen doesn’t simply enter the body and disappear.

It still needs to be processed, transformed and eventually removed.

Much of this work happens through the liver and the gut using a series of enzymes, nutrients and metabolic pathways.

This isn’t about “detoxing” hormones or following restrictive diets.

Nor is it something to be frightened by.

Rather, it’s a reminder that taking HRT and supporting your overall health are part of the same conversation.

Your liver requires adequate nutrition.

Your gut plays an important role in removing used oestrogen from the body.

Eating plenty of fibre and colourful plant foods—including cruciferous vegetables such as broccoli, cauliflower, cabbage and rocket—helps support these natural processes.

This is another beautiful example of why I don’t separate hormones from nutrition, movement or lifestyle.

They’re all supporting the same body.

Where Does the DUTCH Test Fit In?

Some women ask whether they should have hormone testing before considering HRT.

In my own clinical practice, I sometimes use the DUTCH test when there’s a clear reason to explore hormone production or metabolism in more detail.

It can provide valuable additional information in certain situations.

However, it isn’t a test that every woman needs before starting HRT, nor should it be used on its own to decide whether HRT is appropriate.

That decision should always take into account your symptoms, your medical history, your family history, your individual preferences and a conversation with a suitably qualified menopause-informed prescriber.

Testing can sometimes add another piece to the puzzle.

But it isn’t the whole picture.

The Most Important Thing I Hope You Take Away

If there’s one message I’d love you to leave with after listening to this episode, it’s that…

You don’t have to choose between HRT and a whole-body approach.

For many women, the most supportive approach is bringing the two together.

Supporting your hormones.

Supporting your nutrition.

Supporting your sleep.

Supporting your strength.

Supporting your nervous system.

Because all of those things influence one another.

HRT isn’t about replacing healthy habits.

It’s about supporting your changing physiology alongside them.

Whether you ultimately decide to take HRT or not, understanding your body is one of the most empowering things you can do during perimenopause.

And that’s exactly what I hope this episode helps you do.

Listen to the Episode

In this episode of Empowered Perimenopause, I explore what HRT actually is, why women have such different experiences with it, how the guidance has evolved over time, common myths, body-identical hormones, where the DUTCH test fits in, and why I believe HRT should always be viewed as one part of a wider whole-body approach to health.

🎧 Listen to Episode 99: What I Wish Every Woman Knew Before Starting HRT

Continue the conversation inside Midlife Thrive

If this episode resonated with you and you’re looking for ongoing support, I’d love to welcome you into Midlife Thrive.

Midlife Thrive is my online membership designed to help women understand what’s happening in their bodies during perimenopause and beyond.

Inside, you’ll find evidence-informed education, practical guidance, monthly live Q&A sessions, resources and a supportive community of like-minded women navigating this stage of life together.

You don’t have to figure it all out on your own.

You can find all the details by following the link below.

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Feel free to email me at francesca@francescaliparoti.com or DM me on Instagram if you have any questions.

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Have questions or ideas for future topics or guests? I’d love to hear from you. Get in touch me at francesca@francescaliparoti.com

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HELLO! I'm fRANCESCA

My goal and passion in life is to empower women with the knowledge and information they need to navigate their 40s, aka perimenopause. I want all women to know exactly what happens in their body and brain as their hormones behave differently in their 40s. And what they can do! 

I have over 10 years experience working as a Nutritional Therapist, having chosen to specialise in the area of perimenopause 5 years ago.

I hold a Diploma in Nutritional Therapy from the Institute for Optimum Nutrition and I am a member of the British Association for Applied Nutrition and Nutritional Therapy (BANT) and of the Complementary and Natural Healthcare Council (CNHC).

FRANCESCA LIPAROTI



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