
Feeling more stressed, wired, or emotionally fragile in your 40s? You’re not imagining it.
In this episode, we explore why stress feels so much more intense in perimenopause and what your hormones, brain, and nervous system have to do with it.
You’ll learn about the HPA axis (your body’s internal stress system), how it’s affected by erratic oestrogen and declining progesterone, and why supporting it is essential for hormone balance and long-term wellbeing.
We also dive into how stress impacts your ability to make DHEA, testosterone, oestrogen, and progesterone, especially post-menopause, and how everyday habits like blood sugar regulation, sleep, nervous system support, and even adaptogens can make a big difference.
In this episode, I cover:
- What the HPA axis is and how it works
- How the hormone shifts of your 40s affect stress resilience
- Why cortisol increases as oestrogen and progesterone fluctuate
- The role of your adrenal glands in peri and postmenopausal hormone production
- Why “adrenal fatigue” isn’t an accurate phrase and what really needs support
- Simple, powerful ways to support your nervous system daily
- How everyone’s unique perceived stress shapes their hormonal response
- Why NOW is the time to prioritise rest, nourishment, and nervous system regulation
Whether you feel like you’re running on fumes or just want to feel more grounded in this phase of life, this episode is your roadmap to understanding what’s really going on when it comes to perimenopause and stress, and how to reclaim your calm.
Tune into episode 45 now and start supporting your stress response in a way that truly aligns with your midlife body.
Want more support? Join me inside Midlife Thrive, my monthly membership where we walk through every pillar of hormone health together, step by step. Or, book a free discovery call HERE to talk about working together one to one.
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Get in touch!
If you have any questions from this episode that you’d like me to address on a future episode or if you have suggestions for topics and or guests you’d like me to cover and chat with on the show, let me know! You can email me on francesca@francescaliparoti.com or drop me a DM on Instagram.


