
Are your perimenopause symptoms feeling more intense than expected? Maybe you’re experiencing extra issues like rashes, hives, allergies, insomnia, anxiety, or heart palpitations? If this sounds like you, you might be dealing with high histamine, a hidden culprit that can make the perimenopause experience feel harder, for many women.
In this episode, I dive into how fluctuating oestrogen levels in perimenopause can trigger histamine overload and even mast cell activation (MCAS), leading to a wide range of symptoms like migraines, heavy periods, brain fog, anxiety, and more.
You’ll learn:
- Why oestrogen spikes drive up histamine
- How histamine can drive up oestrogen (it’s a vicious cycle!)
- How histamine can fuel neurological symptoms like anxiety, insomnia, migraines, and hot flushes
- The role of leaky gut and declining progesterone in worsening histamine issues
- Why nervous system support is so impactful and ways to support it
- What foods and supplements can help
- Other natural and medical ways to reduce histamine
This episode is essential if your perimenopause journey feels like more than “just hormones.”
Listen to episode 44 now and empower yourself with this missing piece of the puzzle!
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If you have any questions from this episode that you’d like me to address on a future episode or if you have suggestions for topics and or guests you’d like me to cover and chat with on the show, let me know! You can email me on francesca@francescaliparoti.com or drop me a DM on Instagram.


