Perimenopause Creates A Whole-Body Systems Shift, Requiring A Whole-Body Approach

Perimenopause Creates A Whole-Body Systems Shift, Requiring A Whole-Body Approach

After about age 35, women move into the life phase known as perimenopause, which is the start of the body’s slow and gradual transition towards eventually achieving menopause. Menopause is reached after a woman has gone 12 consecutive months without having a period, and the journey to that point can be a rocky one, this is perimenopause.

In simple terms, perimenopause is characterised by changes in the behaviour of oestrogen along with a decline in progesterone (you can read my perimenopause 101 blog here to learn more).

It’s not only about oestrogen and progesterone

However, perimenopause isn’t only an imbalance between oestrogen and progesterone. It’s a phase in a woman’s life when many other hormones and systems are being disrupted, which is causing various metabolic shifts that affect her physically, mentally, and emotionally. It’s a WHOLE body systems shift and so we need to take a WHOLE body systems approach when looking to support the body through it.

Not only is oestrogen erratic (and higher) and progesterone declining, we also have more cortisol, less stable blood sugar, more insulin, less muscle mass, and less thyroid hormone. Furthermore, digestion can be disrupted and there can even be some immune dysregulation and more inflammatory processes at play.

This all starts to bring symptoms that you likely didn’t have to deal with 10, 5, 2 and even 1 years ago. You might notice that you’re reacting differently to certain things in your 40s such as your exercise, late nights, certain foods, alcohol, and stress.

Sound familiar?

Address your health and lifestyle

The more areas of our health and aspects of our lifestyle that need attention (e.g., stress, sleep, gut, work, finances, relationships, alcohol consumption), the more symptoms we will feel.

In your 20s and first half of your 30s your hormones were way more resilient than they are in your 40s. In your 20s and 30s they were less likely to be knocked off balance by factors such as how you exercised, late nights, alcohol, watching TV until late, certain foods/eating styles, and stress.

In perimenopause it’s a different story. Here your hormones are less resilient and they really do start reacting to your nutrition and lifestyle choices. This is good news as it means making positive changes to your nutrition and lifestyle habits can make a BIG difference to your experience of perimenopause by significantly minimising and even eliminating some or all of your symptoms!

Oestrogen and progesterone’s shifts knock on to all body systems

In your 40s, oestrogen gets erratic (sharp highs followed by sharp drops) and you don’t manage to ovulate as many months as you did before, which results in no progesterone being made in those months, which leaves oestrogen alone to dominate your entire cycle instead of being balanced out by it’s partner hormone.

This picture comes with consequences. In the early part of perimenopause (late 30s to mid 40s), oestrogen is actually higher than ever before, sometimes even by 3-fold! It only starts its decline in your late 40s (sometimes mid 40s but more commonly later).

Whether a person is in the higher or declining oestrogen stage, it’s always erratically fluctuating. It’s actually progesterone that we start to lose first, not oestrogen.

Impact of oestrogens erratic fluctuations

The sharp drops:
Insulin resistant cells, brain fog, dip in mood, migraines, hot flushes, weight gain, anxiety, irritability.

The high points:
Heavy periods, clots, breast pain, mood swings, headaches, histamine reactions, weight gain.

Here are some things to address to support oestrogen balance

1) Taper the oestrogen rollercoaster and higher oestrogen levels by supporting the detoxification processes in your liver responsible for clearing out used oestrogen. This keeps things as balanced as possible. There is a specific enzyme called COMT (Catechol-O-methyltransferase), which needs to be working well for this detox process to work efficiently. There are also a couple of important pathways called glucuronidation and methylation that are crucial here. Click here to read my blog on how to support oestrogen detoxification.

2) Care for your gut microbiome. This is the collection of bacteria that live in your gut. An unhealthy balance of bacteria here increases the chances of used oestrogen being sent BACK into your body for circulation and the more more symptoms of ‘unopposed’ oestrogen. Less than once daily bowel movements can also increase oestrogen in circulation. Read my blog on the gut and oestrogen clearance here.

3) Reduce your exposure to/intake of ‘endocrine-disrupting chemicals’. Also known as xenoestrogens, such as plastics, pesticides, and chemicals found in commercial body and hair care, perfumes, and household cleaning products and detergents. They contain chemicals that ‘look like’ oestrogen and once inside the body they take the place of real oestrogen inside the cells, causing hormone havoc and increasing your total load of oestrogen. Filter your water, use glass, ceramic or stainless steel for cooking, heating, storing and drinking and switch to cleaner skincare brands such as Green People, Antipodes, Sukin, Ren, Neal’s Yard and Tropic and cleaner household cleaning and detergent brands such as Bio-D, Method and Attitude.

Impact of declining progesterone

Progesterone gradually starts declining from your mid or late 30s but the decline is more significant around mid 40s. You only make progesterone when you ovulate and ovulation becomes harder and harder to achieve the further through your 40s you go.

In the earlier part of perimenopause you might start having the occasional cycle where you didn’t manage to ovulate, which might not be so impactful. But as you move through your 40s, non-ovulatory cycles become more and more likely, leaving you progesterone deficient more months than not.

Symptoms you might start to notice as a result of not making progesterone include:

  • Trouble falling and or staying asleep at night, disrupted sleep
  • Anxiety that’s particularly heightened, increased feelings of stress
  • Lowered immunity (even autoimmunity in some cases)
  • Shorter menstrual cycles, spotting between periods, heavier periods including clotting and flooding
  • Irritability and low mood
  • Breast pain
  • Fatigue (brain and body), headaches
  • Water retention/all over bloating
  • Changes in cognition or memory

The good news is you CAN support your body to ovulate (so that you make progesterone) more months than it would have done without the intervention.

Here are some things to address:

1) Stress is one of the biggest reasons why we might not ovulate some months and it HAS to be the first thing to address. Look at areas where you can make changes that can help to reduce your life load, and then start to nourish and support your nervous system DAILY to cope better with the inevitable stressors of modern life. Simple daily restorative habits such as deep breathing exercises and meditation (even 3-5 minutes a day has been shown to be impactful), mindful walks through nature/green spaces, yoga (even 5-10 minutes), more laughter and joy, and talking and somatic therapies are all powerful ways to do this.

2) Support insulin sensitivity (read my blog on this here) because insulin resistance can cause irregular ovulation or even block it completely. This is all about supporting good blood sugar regulation via your diet, sleep, stress, exercise, alcohol etc.

3) NOURISH your body. The ovulatory process is energy, calorie and nutrient-expensive. This ISN’T a time to be low calorie or low fat, or to be eating one meal a day or “OMAD” – please no!! You must be well nourished. Eat ENOUGH food/calories coming from a variety of quality protein sources, healthy fats, colourful veg and complex/slow-release carbohydrates. This will allow you to get adequate macronutrients and also the key micronutrients needed for ovulation to occur successfully such as all of the B-vitamins, coQ10, vitamin D, iodine, magnesium, selenium, zinc. You also need adequate cholesterol to make progesterone after ovulation so don’t avoid cholesterol foods!

4) Support your thyroid health. An under-active thyroid gland robs your ovaries of the cellular energy they need to ovulate and elevates prolactin, a hormone that suppresses ovulation. Check your thyroid health markers by way of a FULL thyroid panel that includes not just TSH and T4 PLUS Free T4, Free T3, Total T4, Total T3, Reverse T3, and thyroid antibodies (TG and TPO). Your doctor will likely only test for T4 and TSH so for a full thyroid panel you can go via FunctionalDX or Genova Diagnostics labs, which are practitioner-led only so you would need to be working with someone like myself or similar. Or, you can go it alone and order a Thyroid Panel with Medichecks, (which doesn’t include the marker for Reverse T3).

What about when ovulation just becomes too hard for the body to achieve regardless of making these changes?

This is when you might want to speak to your doctor about taking body identical (NOT a progestin) progesterone. In the earlier stages of perimenopause the answer is likely not to use both progesterone AND oestrogen HRT because remember I said that in the earlier years oestrogen is still high and sometimes MUCH higher than it ever was.

NOTE: The “progesterone” found in the hormonal IUD or oral contraceptive/hormonal medication is NOT progesterone in it’s natural, body identical form, rather it’s in the form of progestin which is an synthetic form with a different molecular structure to progesterone and so it doesn’t different (not so helpful) things in the body.

I hope you can see how important it is to support the body on a holistic level rather than simply look to fix one hormone or system. A 360° approach is needed as per my diagram below. If you need help to work out which of these areas YOU need to address I would love to help you. This is what I help women with day in day out in my practice. Click here for info on ways to work with me and to book in an exploratory chat with me!

Lots of love,
Francesca xx


My Thrive Through Perimenopause Course teaches you everything you need to know to support your body and hormones to THRIVE in your 40s (and beyond!). There is a live programme option (fortnightly group Zoom calls and private Facebook group) or a self study option (no calls, just access to the course content membership site and private Facebook group). Both options give you LIFETIME access to the course content, including any updates made as things evolve. Click here for more info and to buy/join! Or if 1-2-1 support is a better fit for you, click here for info.

Hi, I'm Francesca

I’m a Registered Nutritional Therapist who helps womens in their 40s find vibrant health and vitality, and thrive through perimenopause and beyond.

With nearly 10 years of experience working with hundreds of people, I empower and support women to support their bodies and hormones for a smooth and happy ride in their 4os.

Through our work together, clients have improved their energy, their periods and cycles, their mood, sleep, brain fog and digestion, and learned how to better manage their weight.

I am here to help you get back to YOU so you can have a fantastic time in your 40s.

My signature nutrition and lifestyle coaching approach to supporting women with their health and wellbeing is refreshing, down-to-earth and realistic.

Download the Free Guide

A FREE, no-nonsense PDF guide to Mastering Perimenopause and learn how to master your hormones in your 40s for more energy, better sleep, balanced mood, easier periods and so much more.


Learn more about my signature course – Thrive Through Perimenopause – to start taking care of your hormone health once and for all, for a MUCH smoother ride in your 40s and beyond!

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