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Oestrogen Highs and Lows: Understanding the Perimenopause Roller-Coaster

If your periods have become horribly heavy and unpredictable, your sleep is shot, and you’re suddenly wondering if you have ADHD… you’re not alone. This is perimenopause, and it isn’t about ageing, it’s hormonal chaos.

Let’s unpack what’s really going on.

The Symptom Storm

Lots, if not most, women in perimenopause will experience some sort of combination of:

  • Heavy, flooding periods
  • Irregular cycles
  • Swollen, tender breasts
  • Anxiety and irritability
  • Sleep disturbances
  • Migraines

Other common symptoms include:

  • Trouble focusing or feeling “wired but tired”
  • Feeling less resilient to stress
  • Starting to feel “not like yourself” anymore
  • An emergence (or diagnosis) of neurodivergent traits, such as ADHD

These symptoms aren’t random or imagined and there is nothing wrong with YOU. There’s a physiological reason behind all of it.

What’s Really Happening?

Perimenopause isn’t simply about “getting older”, it’s about your hormones shifting.

  • Oestrogen becomes unpredictable
  • Progesterone is consistently declining
  • Cortisol jumps in, adding to the chaos

The real roller-coaster? Oestrogen levels can become up to three times higher than usual, and fluctuate wildly, while progesterone remains consistently low. This imbalance is what drives many of the symptoms.

What’s Causing the High Oestrogen?

Enter: Inhibin, a hormone that normally keeps the release of Follicle Stimulating Hormone (FSH) in check.

During perimenopause, inhibin levels start to drop, which removes that “brake” on FSH. Without inhibin’s regulation, FSH levels rise significantly, and this drives:

  • Multiple follicles being recruited and stimulated each cycle
  • More oestrogen being produced as a result

So instead of a smooth hormonal rhythm, we get extreme hormonal volatility, leading to both oestrogen highs and lows, sometimes in the same month.

The Impact of This Hormonal Volatility

This “double dose” of oestrogen, plus its erratic nature, can lead to:

  1. Heavy bleeding: Oestrogen overstimulates the endometrial lining, making it over-thicken. Cue: heavy, flooding periods.
  2. Breast tenderness: Oestrogen receptors in breast tissue respond by growing (aka proliferating), making breasts feel swollen and sore.
  3. Mood and focus issues: Oestrogen influences brain chemicals like dopamine and serotonin, both vital for mood, memory, motivation, and sleep. So when oestrogen dips, you may feel low, foggy, scattered, or “off.”

Serotonin also plays a crucial role in sleep, as it’s the precursor to melatonin — your sleep hormone.

What You Can Do About It

The good news? You don’t have to just “deal with it.” Supporting your body can dramatically reduce how chaotic perimenopause feels.

Lifestyle habits and nutrition have a huge impact on riding out the oestrogen highs and lows with more ease.

Practical Support Tips

Here’s what I recommend starting with:

Prioritise Sleep & Circadian Rhythm

  • Consistent bed and wake times
  • Morning daylight exposure to anchor your body clock

Focus on Blood Sugar Balance

  • No skipping meals
  • Eat protein with every meal
  • Choose slow-release carbs to stabilise energy and mood

Key Nutrients to Support Hormone & Brain Function

  • Magnesium
  • B Vitamins — especially B12, B6, and folate (B9)
  • Omega-3 fatty acids
  • Protein — essential for hormone and neurotransmitter production
  • Iron (check ferritin) — especially important if your periods are heavy

Support Your Stress Response

  • High cortisol adds fuel to the hormonal fire
  • Prioritise nervous system regulation through:
    • Breathwork
    • Setting boundaries
    • Stress management techniques like journaling, gentle movement or guided meditation

You’re Not Alone — and You Can Feel Better

My podcast, Empowered Perimenopause, is dedicated to helping you navigate this transition. I cover my four foundational health pillars, as well as more advanced support when you’re ready to go deeper. These are the exact steps I walk through with one-to-one clients and inside my Midlife Thrive programme.

You don’t have to white-knuckle it through this transition, there’s a better way!

Ready for more personalised gut support? Book a free discovery call with me to explore how we can work together. 

Hi, I'm Francesca

I’m a Registered Nutritional Therapist (mBANT, CNHC), podcast host, and founder of the Midlife Thrive Community.

I help women navigate perimenopause with evidence-based nutrition and lifestyle guidance, so they can better understand their changing bodies, feel more confident in their health decisions, and know they don’t have to figure it all out alone.

I qualified as a Nutritional Therapist in 2013, and for more than a decade I’ve had the privilege of supporting women through some of the biggest changes in their lives.

Now, as I’m navigating perimenopause myself, my passion has only grown stronger.

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Francesca Liparoti - Free Perimenopause Quiz

Free Perimenopause Quiz

Stop guessing about your hormones! This complimentary Perimenopause Quiz is designed to help you pinpoint your exact stage and understand your unique symptoms. Get instant, actionable steps to feel your best and start thriving in midlife.